Soybean Tempeh Extract on Improving Oxidative Stress, Angiogenic, Cardiovascular Dysfunction, And Fetal Outcome in A Rat Model of Preeclampsia
DOI:
https://doi.org/10.48048/tis.2026.11240Keywords:
Angiogenic, Cardio Vascular, Oxidative stress, Preeclampsia, Soybean Tempeh, Angiogenic, Cardio vascular, Oxidative stress, Preeclampsia, Soybean tempehAbstract
Preeclampsia is a pregnancy complication that affects multiple organs. Antioxidant approaches have been widely studied to address it, but their bioavailability is limited. This study aims to analyze effects of Soybean Tempeh Extract (STE) on improving oxidative stress, cardiovascular function, angiogenic and fetal weight in preeclamptic rats. A total of 30 Sprague Dawley pregnant rats were divided into five groups: Normal, negative control, positive control (MgSO4), Treatment 1 (STE), and Treatment 2 (STE + MgSO4). Induction of preeclampsia was carried out with L-NAME, and STE was given at a dose of 400 mg/kgBW/day. MDA, NT-proBNP, sFlt-1, Angiotensin II and urine protein levels were measured using ELISA or other biochemical methods. Examination of the labyrinthine/junction zone ratio and ventricular thickness using histology. Measurement of blood pressure and protein is measured periodically. Data were analyzed by one-way ANOVA and repeated-measure ANOVA. STE significantly reduced MDA, NT-proBNP, sFlt-1, Angiotensin II, blood pressure, proteinuria, and fetal weight (p < 0.001) and improved the labyrinthine/junction ratio in histopathology placental tissue (p < 0.001) compared to the negative control group. Heart ventricular thickness in histopathology also showed similarities to the normal group although not significant. STE improves clinical and molecular parameters in preeclamptic rats, especially in reducing oxidative, angiogenic, cardiovascular stress, and fetal weight. Soybean tempeh extract has the potential as a local food-based adjuvant therapy in efforts to improve preeclampsia.
HIGHLIGHTS
Soybean tempeh is a functional food with numerous benefits, including antioxidant and ACE inhibitor activity in hypertension. This study demonstrated the effects of tempeh extract on improving oxidative stress, angiogenic effects, and cardiovascular function in a rat model of preeclampsia.
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