Enhanced Cancer Biomarker Detection using Fe3O4 Magnetic Nanoparticles: Synthesis, Surface Modifications and Diagnostic Applications: A Review
DOI:
https://doi.org/10.48048/tis.2024.8519Keywords:
Biocompatibility, Biomarker identification, Cancer detection, Drug delivery, Early diagnosis, Fe3O4 magnetic nanoparticles, Nanoparticle synthesis, Surface modificationAbstract
Fe3O4 magnetic nanoparticles exhibit significant potential for cancer detection due to their unique magnetic properties and versatility. This review examines their role in enhancing cancer biomarker detection, focusing on synthesis methods, surface modifications and diagnostic accuracy. Fe3O4 nanoparticles serve as sensitive MRI contrast agents, facilitating early cancer diagnosis and improving patient prognosis. Synthesis techniques influence their properties, morphology and dimensions, which affect performance. Surface modifications enhance targeting and reduce immunological reactions, enabling precise biomarker detection and effective drug delivery to tumours, minimizing damage to healthy tissue. Despite these advantages, challenges remain in optimizing delivery efficiency and overcoming medication resistance. Further research is required to understand the pharmacokinetics and pharmacodynamics of these nanoparticles, including their distribution, metabolism and physiological impacts. This review provides insights into the potential of Fe3O4 magnetic nanoparticles as cancer detection agents, aiming to guide future research towards developing safer and more efficient applications in medical diagnostics and treatment.
HIGHLIGHTS
- Fe3O4 magnetic nanoparticles exhibit unique magnetic properties that are highly effective in detecting cancer biomarkers.
- These nanoparticles enable early cancer diagnosis by identifying biomarkers at low concentrations with high sensitivity.
- The review assesses various synthesis techniques for Fe3O4 magnetic nanoparticles to optimize their detection capabilities.
- Exploration of surface modification strategies to enhance the functionality and efficacy of Fe3O4 nanoparticles in cancer biomarker detection.
- Enhanced diagnostic accuracy through the application of Fe3O4 magnetic nanoparticles, promising improved outcomes in cancer detection technologies.
GRAPHICAL ABSTRACT
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