Tacca chantrieri Rhizome Extract Induces Apoptosis and Inhibits Colony Formation and Migration in Triple-Negative, HER2+, and ER+ Breast Cancer Cell Lines
DOI:
https://doi.org/10.48048/tis.2025.10525Keywords:
Tacca chantrieri, Breast cancer, Anti-cancer agent, Apoptosis, Cell migration inhibitionAbstract
Breast cancer is the most common cancer in females worldwide, and standard chemotherapy often causes significant side effects. Tacca chantrieri, a plant used in traditional medicine, contains bioactive compounds with anti-cancer properties. This study aimed to evaluate the anti-cancer activity of T. chantrieri rhizome extract (TCE) on breast cancer cell lines. The rhizomes of T. chantrieri were extracted with 95% ethanol and used to treat MDA-MB-231, MCF-7, and SK-BR-3 breast cancer cell lines. Cell viability was assessed using the MTT assay. Apoptosis was evaluated by annexin V and propidium iodide staining, while colony formation and cell migration were assessed using clonogenic and wound healing-scratch assays, respectively. The results showed that TCE significantly reduced cell viability, induced apoptosis, and inhibited colony formation and migration. In conclusion, TCE exhibits anti-cancer activity against breast cancer cells, highlighting its potential for further development as an alternative treatment for breast cancer.
HIGHLIGHTS
- T. chantrieri rhizome extract (TCE) exhibited anti-cancer breast activity.
- TCE reduced the viability of MDA-MB-231, MCF-7, and SK-BR-3 cell lines.
- TCE induced apoptosis of MDA-MB-231, MCF-7, and SK-BR-3 cell lines.
- TCE inhibited colony formation and migration of MDA-MB-231, MCF-7, and SK-BR-3 cell lines.
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