Aristolactams and Flavanones from Dasymaschalon wallichii (Hook.f. & Thomson) Jing Wang & R.M.K.Saunders and Their α-Glucosidase Inhibitory Activity

Authors

  • Panom Winyayong School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
  • Passakorn Teerapongpisan Center of Chemical Innovation for Sustainability, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
  • Thanakorn Mongantha Center of Chemical Innovation for Sustainability, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
  • Patcharapol Siliwelawan Center of Chemical Innovation for Sustainability, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
  • Chama Thamjamnein Center of Chemical Innovation for Sustainability, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
  • Pakit Kumboonma Department of Applied Chemistry, Faculty of Science and Liberal Arts, Rajamangala University of Technology Isan, Nakhon Ratchasima 30000, Thailand
  • Surat Laphookhieo Center of Chemical Innovation for Sustainability, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
  • Phunrawie Promnart School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand

DOI:

https://doi.org/10.48048/tis.2024.8429

Keywords:

Dasymaschalon wallichii, Anonaceae, α-glucosidase inhibitory activity, Aristolactam alkaloids, Flavonoids, Chalcone

Abstract

The first phytochemical investigation of the twig and leaf extracts of Dasymaschalon wallichii led to the isolation and identification of 10 compounds, including 6 airstolactam alkaloids (1-6), 3 flavonoids (7-9) and one chalcone (10). The structures were elucidated through the analysis of NMR spectroscopic data and comparisons with those reported in the literature. Compounds 1-4 and 7-10 were evaluated for their α-glucosidase inhibitory activity. Among them, aristolactam AII (1) and 8-formyl-5,7dihydroxyflavanone (8) showed α-glucosidase inhibitory activity with IC50 values of 62.9 and 83.9 μM, respectively, which are better than the positive control (acarbose, IC50 = 178.2 μM). The potential binding modes of active compounds with α-glucosidase were also analyzed by molecular docking.

HIGHLIGHTS

  • The first phytochemical investigation of Dasymaschalon wallichii resulted in the isolation and identification of 10 compounds.
  • Compounds 1 and 8 showed α-glucosidase inhibitory activity with IC50 values of 62.9 and 83.9 μM, respectively.
  • The molecular docking of compounds 1 and 8 were studied.

GRAPHICAL ABSTRACT

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Published

2024-10-15

Issue

Vol. 21 No. 11 (2024): Trends in Sciences, Volume 21, Number 11, November 2024

Section

Research Articles

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