Kinetic Studies for the Release of Hydroxychloroquine Sulphate Drug (HCQ) In-vitro in Simulated Gastric and Intestinal Medium from Sodium Alginate and Lignosulphonic Acid Blends
DOI:
https://doi.org/10.48048/tis.2023.5318Keywords:
Sodium alginate, COVID 19, Lignosulphonic acid, HCQ, Control drug release, Drug kinetics, Biopolymer, CrosslinkingAbstract
Biodegradable polymeric blends are used to study the controlled release of Hydroxychloroquine sulphate (HCQ) as the model drug used extensively in COVID-19 treatments. HCQ drug is loaded in sodium alginate (NaAlg) and lignosulphonic acid (NaLS) blends as matrix are crosslinked using calcium chloride solution. Its release is evaluated in different pH mediums of simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The HCQ release data obtained during experimentation is used to study kinetics using different models to investigate polymeric relaxation's drug diffusion and mechanism in water-soluble HCQ drug. The drug release mechanism best fits the Higuchi model with Fickian diffusion as the primary polymeric relaxation mechanism.
HIGHLIGHTS
- Biodegradable polymer blends of sodium alginate and lignosulphonic acid are loaded with Hydroxychloroquine sulphate to demonstrate and evaluate drug release kinetics in simulated gastric and intestinal gastric fluid
- Different kinetic models are applied for experimental data to study drug diffusion and polymer relaxation mechanism. Experimental values reveal that pH medium influences drug release
- The hydroxychloroquine sulphate drug release for extended period in simulated fluids in-vitro proves possible usage for controlled drug delivery applications
GRAPHICAL ABSTRACT
Downloads
References
EA Hosny and AAM Al-Helw. Effect of coating of aluminum carboxymethylcellulose beads on the release and bioavailability of diclofenac sodium. Pharmaceutica Acta Helvetia. 1998; 72, 255-60.
EAE Fattah, DJW Grant, KE Gabr and MM Meshali. Physical characteristics and release behavior of salbutamol sulfate beads prepared with different ionic polysaccharides. Drug Dev. Ind. Pharm. 1998; 24, 541-7.
R Bodmeier and O Paeratakul. Spherical agglomerates of water-insoluble drugs. J. Pharmaceut. Sci. 1989; 78, 964-7.
D Narayanan, GJ Pillai, SV Nair and D Menon. Effect of formulation parameters on pharmacokinetics, pharmacodynamics, and safety of diclofenac nanomedicine. Drug Deliv. Translational Res. 2019; 9, 867-78.
T Abudula, K Gauthaman, A Mostafavi, A Alshahrie, N Salah, P Morganti, A Chianese, A Tamayol and A Memic. Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds. Sci. Rep. 2020; 10, 20428.
SS Rajan, VL Cavera, X Zhang, Y Singh, ML Chikindas and PJ Sinko. Polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis. Antimicrob. Agents Chemother. 2014; 58, 2747-53.
A Smith and LM Hunneyball. Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration. Int. J. Pharmaceut. 1986; 30, 215-20.
BL Bhaskar and SA Kumar. Development and validation of two spectrophotometric methods for the estimation of Dronedarone impurity molecule. Mater. Today Proc. 2021; 46, 2940-4.
A Thakur and SG Reddy. Silver Nanocomposite Hydrogel for pH responsive controlled drug release applications. J. Bionanosci. 2018; 12, 780-7.
KJ McHugh. Employing drug delivery strategies to create safe and effective pharmaceuticals for COVID-19. Bioeng. Translational Med. 2020; 5, e10163.
TC Ho, YH Wang, YL Chen, WC Tsai, CH Lee, KP Chuang, YMA Chen, CH Yuan, SY Ho, MH Yang and YC Tyan. Chloroquine and Hydroxychloroquine: Efficacy in the treatment of the COVID-19. Pathogens 2021; 10, 217.
M Gahlyan and S Jain. Oral controlled release drug delivery system - a review. PharmaTutor 2014; 2, 170-8.
AG Prasanth, AS Kumar, BS Shruthi and S Subramania. Kinetic study and in vitro drug release studies of nitrendipine loaded arylamide grafted chitosan blend microspheres. Mat. Res. Express 2019; 6, 125427.
V Pillay and R Fassihi. In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract II. Physicochemical characterization of calcium-alginate, calcium-pectinate and calcium-alginate-pectinate pellets. J. Contr. Release 1999; 59, 243-56.
B Thu, P Bruheim, T Espevik, O Smidsrod, P Soon-Shiong and G Skjak-Braek. Alginate polycation microcapsules: I. Interaction between alginate and polycation. Biomaterial 1996; 17, 1031-40.
GJ Szava. Mechanisms by which organic expanders improve the performance of lead/acid batteries. J. Power Sourc. 1989; 28, 149-53.
M Qiu, Q Wang, Y Chu, Z Yuan, H Song, Z Chen and Z Wu. Lignosulfonic acid exhibits broadly anti-HIV-1 Activity - potential as a microbicide candidate for the prevention of HIV-1 sexual transmission. PLoS One 2012; 7, e35906.
SG Reddy. Controlled release studies of hydroxychloroquine sulphate (HCQ) drug-using biodegradable polymeric Sodium alginate and lignosulphonic acid blends. Rasayan J. Chem. 2021; 4, 2209-15.
SG Reddy. Effect of crosslinking on control drug release of hydroxychloroquine sulphate drug-using alginate beads. Iranian J. Mater. Sci. Eng. 2022; 19, 1-9.
TO Oh, JY Kim, JM Ha, SC Chi, YS Rhee, CW Park and ES Park. Preparation of highly porous gastroretentive metformin tablets using a sublimation method. Eur. J. Pharm. Biopharm. 2013; 83, 460-7.
PL Ritger and NA Peppas. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Contr. Release 1987; 5, 37-42.
NA Peppas and JJ Sahlin. A simple equation for the description of solute release. III. Coupling of diffusion and relaxation. Int. J. Pharm. 1989; 57, 169-72.
LR Shivakumara and T Demappa. Synthesis and swelling behavior of sodium alginate/poly(vinyl alcohol) hydrogels. Turk. J. Pharm. Sci. 2019; 16, 252-60.
SN Pawar and KJ Edgar. Alginate derivatization: a review of chemistry, properties and applications. Biomaterials 2012; 33, 3279-305.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Walailak University
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
