Synthesis, Structural Studies and Antimicrobial Evaluation of Nickel(II) Bis-Complex of Schiff Base of S-Benzyldithiocarbazate
DOI:
https://doi.org/10.48048/tis.2022.1500Keywords:
Nickel(II), Dithiocarbazate, Isatin, Nickel acetate tetrahydrate, Crystal structure, AntimicrobialAbstract
A tridentate nitrogen-oxygen-sulfur (NOS) S-benzyl(2-oxoindolin-3-ylidene)dithiocarbazate, HSBISA (HL1) ligand was synthesized via a condensation reaction between S-benzylditihocarbazate (SBDTC) and isatin. The produced ligand was reacted with nickel(II) acetate salt in 1:2 (metal:ligand) ratio to yield a brown Ni(SBISA)2 complex (2) (SBISA = monoanionic form of HL1). Characterization of HL1 and its Ni(II) complex was performed via elemental analysis, FT-IR, ICP-AES, UV-Vis spectroscopy and mass spectrometry, along with molar conductivity and magnetic susceptibility measurement. Slow evaporation of 2 from DMSO at room temperature led to a structure crystallizing in the monoclinic P21/a space group with a = 18.6860(3), b = 11.3037(2), c = 19.8993(3), b = 112.1897(10), V = 3891.86(11) Å3, wR2 (all data) = 0.0407 and R1 = 0.0386 for data with I > 2σ(I). The nickel(II) metal center is ligated by doubly-deprotonated NOS monoanionic tridentate HL1 ligands forming a neural distorted octahedral Ni(SBISA)2×2DMSO (2a) complex. The antimicrobial assays of both compounds were performed on selected pathogenic bacteria and fungi strains.
HIGHLIGHTS
- Octahedral Ni(II) complex was synthesized using acetate salt
- Compound was characterized via physico-chemical analyses
- Structural studies were resolved via single crystal X-ray diffraction
- Compound 2a crystallized in a monoclinic system (P21/a space group) with cell parameters a = 18.6860 (3), b = 11.3037 (2), c = 19.8993(3), b = 112.1897 (10), V = 3891.86 (11) Å3, wR2 (all data) = 0.0407 and R1 = 0.0386 for data with I > 2σ(I)
- Compound was evaluated for its antimicrobial activity
GRAPHICAL ABSTRACT
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