30 Days Randomized Ginger Ingestion on Blood Lipid and Sugar Levels in Hypertensive Older Women

Authors

  • Prapapimon Pariwat Faculty of Applied Science and Engineering, Khon Kaen University, Khon Kaen 40002, Thailand
  • Kunanya Masodsai Faculty of Sports Science, Chulalongkorn University, Bangkok 10330, Thailand
  • Rungchai Chuanchaiyakul College of Sports Science and Technology, Mahidol University, Nakhon Pathom 73170, Thailand

DOI:

https://doi.org/10.48048/tis.2022.4606

Keywords:

Ginger, Lipid profile, Ageing, Women, Hypertension

Abstract

Gingers is widely used as the complimentary household herbal medicine since it promotes varieties of health-protective effects including anti-hyperlipidemia and anti-hypertension. This study aimed to evaluate the effect of a 30-day ginger (Zingiber officinale Roscoe, Zingiberaceae) ingestion on lipid and glucose profiles and blood pressures in hypertensive older women. The randomized double-blinded ginger consumption was designed in normotensive and hypertensive older women. Thirty-two female volunteers were randomly allocated into 4 groups of normotensives and hypertensives without and with ginger consumption, named as normotensive control (NC); normotensive with ginger consumption (NG); hypertensive control (HC) and hypertensive with ginger consumption (HG). On daily basis, the ginger-treated groups (NG and HG) ingested ginger powder at 75 mg/kgBW/day dissolved in 150 mL water after breakfast whereas control groups (NC and HC) received 150 mL water only for 30 days. Data were collected, in the morning, at pre- and post-intervention. Blood lipids, including cholesterol (chol), triglycerides (TG), high density lipoproteins (HDL), and low density lipoproteins (LDL), glucose levels and blood pressures were evaluated and compared from pre- and post-interventions. The results showed that 30-day ingestion of ginger exerted no change in normotensive groups, where alterations of blood lipid profiles were found in hypertensive groups. Both hypertensive groups (HC and HG) showed the significant reductions in SBP (p < 0.05), however, HC showed significantly increase in blood TG and LDL. HG group showed the reduction in TG and unchanged in LDL. There were no significant differences in chol, HDL, glucose levels and health-related performance from either within or between-groups comparisons (p > 0.05). This study primarily shows the minimal duration of 30-day ingestion of dissolved ginger on lowering systolic blood pressure and triglycerides but plays no roles in glycemic control in hypertensive subjects. Ginger might possibly play an important alternative role in alleviating certain health risks in the hypertensive aged females. To build up confidence on its therapeutic effect, more sample size of this local herb is needed in further investigation.

HIGHLIGHTS

  • Ginger is widely reported in traditional medicine to relieve symptoms and certain diseases. This herb is popularly used and easily find in Oriental countries
  • Ginger can be used to minimize the high prevalence of dyslipidemia and hypertension among Thai population, especially in the north and north-east regions
  • The minimum 30 days of ginger ingestion shows some effectiveness on blood lipids and lowers systolic blood pressure in hypertensive elderly
  • Ginger might possibly play additional important roles in alleviating certain health risk in the aged


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References

W Aekplakorn, S Taneepanichskul, P Kessomboon, V Chongsuvivatwong, P Putwatana, P Sritara, S Sangwatanaroj and S Chariyalertsak. Prevalence of dyslipidemia and management in the Thai population, National Health Examination Survey IV, 2009. J. Lipids 2014; 2014, 249584.

A Sriruksa, N Wongpongkham and B Homhuan. The role of women in Isaan culture under a capitalist society. Eur. J. Soc. Sci. 2014; 44, 363-85.

S Sasat and BJ Bowers. Spotlight Thailand. Gerontologist 2013; 53, 711-7.

QQ Mao, XY Xu, SY Cao, RY Gan, H Corke, T Beta and HB Li. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods 2019; 8,185.

H Gholinezhad, H Rashidi, P Salehi, MH Haghighi-zadeh and AZ Javid. Using ginger supplement in adjunct with non-surgical periodontal therapy improves metabolic and periodontal parameters in patients with type 2 diabetes mellitus and chronic periodontitis: A double-blind, placebo-controlled trial. J. Herb. Med. 2019; 20, 100315.

S Dugasani, MR Pichika, VD Nadarajah, MK Balijepalli, S Tandra and JN Korlakunta. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J. Ethnopharmacol. 2010; 127, 515-20.

M Zhang, E Viennois, M Prasad, Y Zhang, L Wang, Z Zhang, MK Han, B Xiao, C Xu, S Srinivasan and D Merlin. Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer. Biomaterials 2016; 101, 321-40.

I Lete and J Alluέ. The effectiveness of ginger in the prevention of nausea and vomiting during pregnancy and chemotherapy. Integr. Med. Insights 2016; 11, 11-7.

S Kumar, K Saxena, UN Singh and R Saxena. Anti-inflammatory action of ginger: A critical review in anemia of inflammation and its future aspects. Int. J. Herb. Med. 2013; 1, 16-20.

AM Bode and Z Dong. The amazing and mighty ginger. In: IFF Benzie and S Wachtel-Galor (Eds.). Herbal medicine: Biomolecular and clinical aspects. 2nd ed. CRC Press, Boca Raton, United Statates, 2011.

H Mozaffari-Khosravi, B Talaei, BA Jalali, A Najarzadeh and MR Mozayan. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Compl. Ther. Med. 2014; 22, 9-16.

P Rasamejam, P Akaratanapol, P Limteerayos and K Khungtumneam. Factors predict health promotion behaviors among Thai muslim with hypertension. J. Nurs. Siam Univ. 2018; 19, 56-68.

MH Gayar, MM Aboromia, NA Ibrahim and MHA Hafiz. Effects of ginger powder supplementation on glycemic status and lipid profile in newly diagnosed obese patients with type 2 diabetes mellitus. Obes. Med. 2019; 14, 100094.

H Tabibi, H Imani, S Atabak, I Najafi, M Hedayati and L Rahmani. Effects of ginger on serum lipids and lipoproteins in peritoneal dialysis patients: A randomized controlled trial. Perit. Dial. Int. 2016; 36, 140-5.

N Khandouzi, F Shidfar, A Rajab, T Rahideh, P Hosseini and MM Taheri. The effects of ginger on fasting blood sugar, hemoglobin A1c, apolipoprotein B, apolipoprotein A-I and malondialdehyde in type 2 diabetic patients. Iran. J. Pharm. Res. 2015; 14, 131-40.

S Mahluji, VE Attari, M Mobasseri, L Payahoo, A Ostadrahimi and SE Golzari. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int. J. Food Sci. Nutr. 2013; 64, 682-6.

R Grzanna, L Lindmark and CG Frondoza. Ginger - an herbal medicinal product with broad anti-inflammatory actions. J. Med. Food 2005; 8, 125-32.

BT Palmisano, L Zhu, RH Eckel and JM Stafford. Sex differences in lipid and lipoprotein metabolism. Mol. Metabol. 2018; 15, 45-55.

WHO expert consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004; 363, 157-63.

G Saravanan, P Ponmurugan, MA Deepa and B Senthilkumar. Anti-obesity action of gingerol: Effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high-fat diet. J. Sci. Food Agr. 2014; 9, 2972-7.

P Manasatchakun, T Choowattanapakorn, A Roxberg and M Asp. Community nurses' experiences regarding the meaning and promotion of healthy aging in northeastern Thailand. J. Holistic Nurs. 2018; 36, 54-67.

P Narongchai ans S Narongchai. Study of the normal internal organ weights in Thai population. J. Med. Assoc. Thai. 2008; 91, 747-53.

P Manasatchakun, P Chotiga, A Roxberg, and M Asp. Healthy ageing in Isan-Thai culture - a phenomenographic study based on older persons' lived experiences. Int. J. Qual. Stud. Health Well Being 2016; 11, 29463.

MA Pereira, RM Weggemans, DR Jacobs, PJ Hannan, PL Zock, JM Ordovas and MB Katan. Within-person variation in serum lipids: Implications for clinical trials. Int. J. Epidemiol. 2004; 33, 534-41.

R Alizadeh-Navaei, F Roozbeh, M Saravi, M Pouramir, F Jalali and AA Moghadamnia. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med. J. 2008; 29, 1280-4.

AEA Elshater, M Salman and M Moussa. Effect of ginger extract consumption on levels of blood glucose, lipid profile and kidney functions in alloxan induced-diabetic rats. Egypt. Acad. J. Biol. Sci. 2009; 2, 153-62.

T Arablou, N Aryaeian, M Valizadeh, F Sharifi, A Hosseini and M Djalali. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. Int. J Food Sci. Nutr. 2014; 65, 515-20.

S Atashak, M Peeri, MA Azarbayjani, SR Stannard and MM Haghighi. Obesity-related cardiovascular risk factors after long-term resistance training and ginger supplementation. J. Sports Sci. Med. 2011; 10, 685-91.

AJ Akinyemi, GR Thomé, VM Morsch, NB Bottari, J Baldissarelli, LS de Oliveira, JF Goularte, A Belló-Klein, T Duarte, M Duarte, AA Boligon, ML Athayde, AA Akindahunsi, G Oboh and MR Schetinger. Effect of ginger and turmeric rhizomes on inflammatory cytokines levels and enzyme activities of cholinergic and purinergic systems in hypertensive rats. Planta Med. 2016; 82, 612-20.

P Azimi, R Ghiasvand, A Feizi, J Hosseinzadeh, M Bahreynian, M Hariri and B Abbasi. Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. Blood Pres. 2016; 25, 133-40.

YS Kim, HW Seo, MH Lee, DK Kim, H Jeon and DS Cha. Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans. Arch. Pharm. Res. 2014; 37, 245-52.

K Masodsai, YY Lin, R Chaunchaiyakul, CT Su, SD Lee and AL Yang. Twelve-week protocatechuic acid administration improves insulin-induced and insulin-like growth factor-1-induced vasorelaxation and antioxidant activities in aging spontaneously hypertensive rats. Nutrients 2019; 11, 699.

K Srinivasan. Ginger rhizomes (Zingiber officinale): A spice with multiple health beneficial potentials. Pharm. Nutr. 2017; 5, 18-28.

EE Mulvihill, AC Burke and MW Huff. Citrus flavonoids as regulators of lipoprotein metabolism and atherosclerosis. Ann. Rev. Nutr. 2016; 36, 275-99.

S Vungarala, KT Venkata and R Krishnan. Blockade of voltage dependent calcium channels lowers the blood pressure through ginger. Int J. Anal. Pharm. Biomed. Sci. 2013; 2, 64-6.

Y Wang, H Yu, X Zhang, Q Feng, X Guo, S Li, R Li, D Chu and Y Ma. Evaluation of daily ginger consumption for the prevention of chronic diseases in adults: A cross-sectional study. Nutrition 2017; 36, 79-84.

HJ Kim, B Kim, EG Mun, SY Jeong and YS Cha. The antioxidant activity of steamed ginger and its protective effects on obesity induced by high-fat diet in C57BL/6J mice. Nutr. Res. Pract. 2018; 12, 503-11.

MA Lebda, NM Taha, MA Korshom, AEA Mandour and AM El-Morshedy. Biochemical effect of ginger on some blood and liver parameters in male New Zealand rabbits. J. Anim. Feed Res. 2012; 2, 197-202.

N de Las Heras, M Valero-Muñoz, B Martín-Fernández, S Ballesteros, A López-Farré, B Ruiz-Roso and V Lahera. Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet. Appl. Phys. Nutr. Metabol. 2017; 42, 209-15.

ZM Al-Amin, M Thomson, KK Al-Qattan, R Peltonen-Shalaby and M Ali. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br. J. Nutr. 2006; 96, 660-6.

Y Li, VH Tran, CC Duke and BD Roufogalis. Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes. Planta Med. 2012; 78, 1549-55.

NB Abdulrazaq, MM Cho, NN Win, R Zaman and MT Rahman. Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats. Br. J. Nutr. 2012; 108, 1194-201.

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Published

2022-06-09

How to Cite

Pariwat, P. ., Masodsai, K. ., & Chuanchaiyakul, R. . (2022). 30 Days Randomized Ginger Ingestion on Blood Lipid and Sugar Levels in Hypertensive Older Women. Trends in Sciences, 19(12), 4606. https://doi.org/10.48048/tis.2022.4606